Eskisehirspor defender Akaminko picked up an ankle injury during the closing stages of the friendly defeat to Holland on Saturday and is out for three months, while Leicester defender Schlupp and Helsingborg midfielder Accam also miss out from the original 26-man selection.
Appiah’s final squad includes 16 players contesting their first World Cup, but there is plenty of experience elsewhere, with captain Asamoah Gyan and Sulley Muntari preparing for their third finals and Jonathan Mensah, Michael Essien, Kwadwo Asamoah, Andre Ayew and Kevin-Prince Boateng about to contest their second.
Ghana travel to Miami for the final stages of their build up to Brazil, with one more friendly to come against fellow finalists South Korea on 9 June. Their World Cup Group G campaign kicks off against the United States on June 16, before meetings with Germany and Portugal.
Goalkeepers: Fatau Dauda (Orlando Pirates), Adam Kwarasey (Stromsgodset), Stephen Adams (Aduana Stars)
Defenders: Samuel Inkoom (Platanias), Daniel Opare (Standard Liege), Harrison Afful (Esperance), John Boye (Rennes), Jonathan Mensah (Evian), Rashid Sumalia (Mamelodi Sundowns)
Midfielders: Michael Essien (AC Milan), Sulley Muntari (AC Milan), Rabiu Mohammed (Kuban Krasnodar), Kwadwo Asamoah (Juventus), Emmanuel Agyemang-Badu (Udinese), Afriyie Acquah (Parma), Christian Atsu (Vitesse Arnhem), Albert Adomah (Middlesbrough), Andre Ayew (Marseille), Mubarak Wakaso (Rubin Kazan)
Forwards: Asamoah Gyan (Al Ain), Kevin-Prince Boateng (Schalke), Abdul Majeed Waris (Valenciennes), Jordan Ayew (Sochaux).
* Squad lists are only official once they have been confirmed and published by FIFA on 5 June at 12:00 CET.
Confederation of African Football (CAF) News