Ghana hopes at the African Nations Cup finals could be in severe danger if they fail to get a result against Mali in Port Elizabeth.
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Ghana, who squandered a 2 goal lead against the Democractic Republic of Congo in their opening match, battle a Mali side that top Group B after beating Niger 1-0 on Sunday.
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Mali will also have the psychological advantage after they beat the Black Stars in the third place play-off at the last Nations Cup in 2012.
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The match at the Nelson Mandela Bay Stadium will show the world two young teams expected to play a prominent role in future competitions, but Ghana's 2-2 draw with the Congolese raised questions over their inexperience and temperament at the highest level.