Barcelona midfielder Xavi has withdrawn from the Spain squad to play Uruguay this week because of a hamstring problem, the Spanish football federation said on Monday.
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The 33-year-old playmaker, who could have earned his 120th cap against the South American champions in Doha on Wednesday, had been examined by the Spanish football federation medical staff after Barca's 1-1 draw at Valencia on Sunday, the federation said on their Twitter feed.
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The world and European champions have already lost Real Madrid midfielder Xabi Alonso because of a groin injury sustained in Saturday's 1-0 defeat at Granada.
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Alonso was replaced in the squad by Atletico Madrid's Mario Suarez, a 25-year-old former youth international with his first call up. The federation did not say if anyone would be brought to replace Xavi.