Carles Puyol is set to win his 100thcap for Spain in Wednesday's friendly against Uruguay in Qatar, while Vicente Del Bosque will equal the record for most games as Spanish coach.
Chelsea's Cesar Azpilicueta, Malaga's Isco and Mario Suarez of Atletico Madrid could all make their debuts in the game against the reigning South American champions at Doha's Khalifa International Stadium.
Victor Valdes should replace Iker Casillas in goal for Spain, and Puyol stand in as captain as he joins Casillas, Xavi Hernandez, Xabi Alonso, Fernando Torres, Andoni Zubizarreta and Raul Gonzalez in La Roja's 100 cap club.