About 300 officers will work at Saturday's FA Cup fifth-round tie between Luton Town and Millwall FC at Kenilworth Road, police said.
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Bedfordshire Police promised "a large and very visible presence", including on trains approaching the town.
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It said policing for the game, which will kick off at 12:45 GMT, was a "slightly larger operation" than the usual arrangements for matches.
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In 1985 violence marred an FA Cup match between the two sides.