Barcelona playmaker Xavi may recover from a hamstring injury in time to feature in Wednesday's Champions League last 16 first leg at Serie A side AC Milan, interim coach Jordi Roura said on Friday.
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The 33-year-old has not featured for the La Liga leaders since a 1-1 draw at Valencia on February 3 and had to pull out of the Spain squad for this month's friendly against Uruguay.
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"We hope that he'll make it but we'll see how things develop," Roura, who is standing in for Tito Vilanova while he recovers from throat surgery, told a news conference.
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As well as Xavi, Barca will be without forward David Villa for Saturday's La Liga game at Granada, Roura said.
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Villa has been in and out of hospital this week for treatment on kidney stones and was not included in the squad for the trip to Andalusia.
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"It was a setback that disrupted his rhythm," Roura said.
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Barca can go 15 points clear of second-placed Atletico Madrid with a win at 14th-placed Granada, who shocked visiting champions Real Madrid by beating them 1-0 this month.
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Atletico, who suffered their first home defeat of the season against Rubin Kazan in the Europa League on Thursday, play at Real Valladolid on Sunday.
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Real, four points behind Atletico in third, host Rayo Vallecano in Sunday's late kickoff.