A first-half header from Nigerian centre-back Danny Shittu gave Millwall a 1-0 win at Blackburn Rovers on Wednesday that set up an FA Cup semifinal at Wembley against Wigan Athletic.
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Shittu, the Millwall captain, struck shortly before halftime to settle the quarterfinal tie, three days on from the hard-fought 0-0 draw between the Championship rivals at the Den on Sunday.
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Millwall are the last non-Premier League side left in the competition and are bidding to emulate their run to the final in 2004, when they lost 3-0 to Manchester United.
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United are due to face Chelsea in the second quarterfinal replay on April 1, with the winners in line to meet Manchester City on April 14.
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A disappointing crowd of under 9 000 witnessed the home side procure the first sight of goal at Ewood Park, but Leon Best's low shot was comfortably saved by David Forde.
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The recalled David Dunn, making his first start since October, then swept a shot wide from a corner, but as the half progressed, Millwall began to assert themselves.
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Chris Taylor lashed a shot narrowly off-target from 20 yards mid-way through the first half, before the breakthrough arrived three minutes from halftime.
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Millwall had just seen a penalty appeal for handball against Jason Lowe dismissed when Taylor swung a corner into the box from the left that the strapping Shittu converted with a powerful downward header.
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It was the first time that Blackburn, owned by Indian poultry firm Venky's, had conceded a goal in this season's competition.
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Rovers coach Michael Appleton introduced Portuguese veteran striker Nuno Gomes at halftime, but the hosts had to wait almost 20 minutes to fashion a chance.