Debutants Malaga kept their Champions League dream alive when Isco and substitute Roque Santa Cruz struck in a 2-0 win at home to 10-man Porto on Wednesday that sent the La Liga side through to the last eight 2-1 on aggregate.
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Playmaker Isco put Malaga ahead with a brilliant curling effort two minutes before halftime and Porto's hopes were dealt a further blow four minutes after the break when midfielder Steven Defour was shown a second yellow card and sent off.
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Malaga probed patiently for a second and Santa Cruz headed into the net from Isco's corner in the 77th minute, moments after coming off the bench.
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With the tie still delicately balanced, Porto threw men forward but Malaga held firm to ensure their name will be included in Friday's draw for the quarterfinals.
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"We are back in the best possible way," Isco told Spanish television broadcaster Canal Plus.
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"This would have been unthinkable only a short time ago it's incredible. Nobody here has ever experienced anything like this and they all deserve it. I think we fully deserved the win. We enjoyed the match and we played our football."
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Porto made much the stronger start at a packed Rosaleda stadium but had to wait until the ninth minute before creating their first genuine chance when Danilo fired a shot over the bar from close to the byline.
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The home side gradually clawed their way back into the match and Porto goalkeeper Helton was forced into an acrobatic save to deny Antunes in the 35th minute.
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A moment of brilliance from Isco finally broke the deadlock two minutes before halftime.
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The Spain Under-21 international picked up the ball outside the area, moved into space and curled a superb shot over Helton into the top left corner.
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The superb Isco came close from a tight angle just after the hour before providing the assist for Santa Cruz's decisive goal on a memorable night for the 20- year-old.