Manchester United will be confirmed as Premier League champions on Monday night if they beat Aston Villa, while an away win would relegate Queens Park Rangers and Reading.
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Manchester City failed to narrow the 13-point gap at the top on Sunday as they suffered a 3-1 defeat at Tottenham Hotspur, presenting Sir Alex Ferguson's side with the opportunity to reclaim the title at Old Trafford with a victory over Villa.
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United have been comfortably clear at the top for some time but have had to wait to get over the line after losing the recent Manchester derby and then dropping points in a 2-2 draw with West Ham United last week.
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However, the Red Devils still have an opportunity to eclipse the Premier League points record of Jose Mourinho's Chelsea, who amassed 95 points in 2005, if they win all their remaining games.
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Ferguson admits that missing out on the title to City last season provided added incentive to get it back, and there will be an air of anticipation as United strike to land a 20th league crown.
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It is a daunting task facing Aston Villa as they try to keep United's celebrations on hold, but Paul Lambert says his players will head to Manchester with no fear.
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Villa are currently just one spot above the drop zone but were boosted over the weekend by defeats for the three clubs in the relegation zone.
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Queens Park Rangers and Reading are now 10 points adrift of safety and will both be relegated on Monday if Villa win, leaving the other sides in the mix scrapping to avoid the final place in the bottom three.
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Wigan's hopes suffered a blow on Saturday as they lost 2-0 to West Ham and Villa can pile the pressure on Roberto Martinez's men by stretching their advantage to six points.
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The gap currently stands at just three, with the teams having played the same amount of games, but Villa are in better form.
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They have won three of their past five matches, although they were held to a 1-1 draw by Fulham last time out.
I heard Robin Van Persie has already scored in less than 2 minutes. Manchester United has won the title already
RVP has scored his second goal on this crucial night. Not only will United win the title, RVP might also be highest goal scorer