Barcelona can secure their fourth La Liga title in five years on Saturday, but the celebrations are likely to be muted with the club facing a mountain to climb in their Champions League semifinal.
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Barca lead second-placed Real Madrid by 13 points with six games left to play, and could move 16 clear with a victory at struggling Athletic Bilbao (1600 GMT).
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That would be enough to deliver them the title should Real then lose at third-placed Atletico Madrid (1800).
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The Catalans, however, will travel back to the Nou Camp with their minds turning to how they might overturn a 4-0 deficit against Bayern Munich four days later.
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The top two are likely to field weakened teams in anticipation of demanding European second legs next week.
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Jose Mourinho's side have publicly given up on the league to focus on Europe and need to recover from a 4-1 drubbing at Borussia Dortmund.
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Only a Barca win and a Real defeat can deliver coach Tito Vilanova's first league title as Madrid hold a superior head-to-head record.
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Barca take on a Bilbao side lying 14th in the standings and in danger of slipping into the relegation battle, while on paper Real have a much- more demanding fixture at the Calderon.
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Atletico have a chance to end almost 14 years of derby pain and to move above their distracted neighbours with a victory, and coach Diego Simeone has challenged his side to seize their opportunity.
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Real are three points ahead of them and hold the edge in head-to-heads should they finish level, after a 2-0 victory at the Bernabeu earlier in the season.
That is really all they can win this season. They better face that right now else they might lose it too. Their reign is over