Iniesta expects Spain's 29-game unbeaten run to come under severe threat when they face Brazil in the FIFA Confederations Cup final today.
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The Barcelona midfielder, who scored his penalty in the shoot-out victory over Italy to ensure Spain's place in the tournament showdown, insisted that the hosts are favourites to win the match.
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"They are favourites because they play at home, because they will have thousands of people behind them," he told COPE.
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"This factor we must make an incentive. There is no challenge as big as beating Brazil in their stadium.
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Brazil are a great team, (they have had) a spectacular tournament and (they have) great players."
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Vicente del Bosque's men, who are eyeing a fourth consecutive international title, have conceded just one goal in the competition but will take on a Brazil side who have scored 11 times in four matches so far.
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The last meeting between the two was a friendly encounter in 1999 that ended goalless.
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Spain's last trip to the Maracana to take on Brazil was 63 years ago, when they suffered a 6-1 loss that remains the second-heaviest defeat in their history.
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Turning his attentions back to his club side, Iniesta also revealed his desire to see Thiago Alcantra stay at Barcelona as interest in the midfielder continues to grow.
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He added: "As a companion and the knowledgeable player he is, I'd love him to stay, but everyone has their vision and has to be happy with what he does."
I just hope he is not saying this because they are the host country. Host or no host, Brazil will beat Spain.