Spain midfielder Cesc Fabregas has dropped out of the squad visiting Ecuador for a friendly next week after injuring his ankle, the world and European champions said on Sunday.
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Fabregas twisted ligaments in his right ankle during Barca's pre-season 3-1 friendly win over a Malaysia XI in Kuala Lumpur on Saturday.
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The 26-year-old had opened the scoring with a header and set up Neymar and Gerard Pique for the other two goals, before limping out of the game.
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The Spanish champions did not say how long the midfielder would be out of action but he is a doubt for their La Liga opener at home to Levante next Sunday.
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Spain coach Vicente del Bosque will not call up a replacement and the team will travel to Guayaquil for Wednesday's game with a squad of 20.
Cesc Fabregas' football career has just reduced in quality because he's not been playing regularly for his club and country.