Mesut Ozil and Willian could be among the players making their first appearances when the Premier League resumes on Saturday, while Tottenham Hotspur will begin life without Gareth Bale.
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No sooner did the transfer window close on September 2 than the international break began, meaning that fans have had to wait close to two weeks for a first glimpse of their clubs' new signings in action.
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Arsenal's capture of Ozil from Real Madrid in a club- record £42.4 million deal stole the deadline-day headlines, and he is expected to make his debut at Sunderland on Saturday.
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The deal made Ozil the most expensive German footballer of all time, but the 24-year-old has played down the significance of his price tag.
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"I would have come here without a fee. That would not be a problem," he told reporters after being officially presented as an Arsenal player on Thursday.
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"Of course I am proud of this, but the most important thing is that the manager trusts me. That was crucial for me and that is why I came to Arsenal."
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The manager, Arsene Wenger, says there is a "possibility" that Ozil will start at the Stadium of Light, where Arsenal will be bidding to record a fifth consecutive win in all competitions.
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Their last league outing saw them prevail 1-0 against north London rivals Tottenham, who host Norwich City on Saturday in the first game since Welsh forward Bale completed his move to Madrid for a reported world-record fee of around £86 million.
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Spurs offset Bale's departure by spending around £110 million on new players and could hand a debut to Danish playmaker Christian Eriksen against Norwich.
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With the Bale saga finally at an end, coach Andre Villas-Boas has urged his players to refocus quickly.
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"What we have to do is move on," he said during Thursday's pre-game press conference.
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On Eriksen, he added: "I think what happened with Christian is a bit like that happened with Wesley Sneijder and Rafael van der Vaart when they were at Ajax.
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"We expect great things of Christian Eriksen and we want to develop him into becoming that sort of important player for us as well."
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Defending champions Manchester United were not nearly as active in the transfer market, but they could hand a debut to £27.5 million new recruit Marouane Fellaini against Crystal Palace on Saturday.