Winger Pablo Hernandez will miss Swansea's first group game in the Europa League, against his former club Valencia on Thursday.
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The 28-year-old Spaniard has been ruled out because of a hamstring strain and will also sit out Sunday's Premier League match at Crystal Palace.
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But Swans striker Wilfried Bony will be fit to face Valencia.
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He sustained a rib injury during Monday's 2-2 Premier League draw with Liverpool at the Liberty Stadium.
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Hernandez was a club-record £5.55m signing when he joined Swansea from his hometown club in August 2012.
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He spent eight years at Valencia in two four-year stints, initially leaving to join Cadiz on loan after coming through the youth system.
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Hernandez also played under current Swans boss Michael Laudrup at Getafe, before returning to Valencia in 2008.
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Having played in the Europa League and Champions League for the Spanish club, he had hoped his friends and family would have the chance to see him in action there for the Swans.
Well the team is still strong with or without him so I believe they should still get a good result even if their opponent is strong too!