Champions Manchester United crashed to a second home Premier League defeat in four days when they lost 1-0 to Newcastle United on Saturday while Jose Mourinho's Chelsea suffered a shock 3-2 loss at Stoke City.
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Luis Suarez-inspired Liverpool climbed to second with a 4-1 romp over West Ham United at Anfield and Manchester City slipped one place to fourth after being held 1-1 at Southampton.
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Tottenham Hotspur travel to bottom club Sunderland later on Saturday while leaders Arsenal, who still have a four-point lead at the top, entertain Everton at The Emirates on Sunday.
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Arsene Wenger's side have 34 points ahead of Liverpool and Chelsea on 30, Manchester City (29), Everton (27) and Newcastle (26).
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Norwich City won 2-0 at West Bromwich Albion while Crystal Palace picked up their second successive victory under new manager Tony Pulis with a 2-0 home win over Cardiff City.
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Newcastle's victory was their first at Old Trafford since February, 1972, while Stoke ended Chelsea's run of three wins and enjoyed their first league success against them since 1975.
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Manchester United manager David Moyes, without suspended England striker Wayne Rooney, made seven changes to the team beaten by Everton on Wednesday but witnessed a forlorn display.
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Newcastle's French midfielder Yohan Cabaye got the only goal with a controlled 10-metre shot after 61 minutes, condemning the hosts to back-to-back home defeats for the first since May 2002. It was also Moyes' third loss as manager in eight home games.
Liverpool are getting stronger every week and that is good for them if they want to qualify for UCL next season.