Chelsea will tackle fellow Premier League heavyweights Manchester City in the stand-out tie of the FA Cup fifth round.
Chelsea booked their place in the last 16 with a 5-1 win at Milton Keynes Dons and were immediately dealt a home game against City, who won 4-0 at Aston Villa on Saturday.
Third-tier Shrewsbury Town, who shocked Championship side Sheffield Wednesday 3-2 in round four, were rewarded with a glamour tie at home to Manchester United.
Meanwhile, Arsenal, seeking a third consecutive FA Cup success, were handed a home tie against second-tier Hull City, who they defeated in the 2014 final.
Tottenham Hotspur will host London rivals Crystal Palace, while another all-Premier League tie sees Everton, 3-0 winners at fourth-tier Carlisle United on Sunday, visit Bournemouth.
Draw:
Chelsea v Manchester City
Reading (II) v West Bromwich Albion or Peterborough (III)
Watford v Leeds United (II)
Shrewsbury Town (III) v Manchester United
Blackburn Rovers (II) v Liverpool or West Ham United
Tottenham Hotspur v Crystal Palace
Arsenal v Hull City (II)
Bournemouth v Everton
Matches to be played February 19-21
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