The AACR Annual Meeting is a gathering central to the global cancer research community, bringing together scientists, clinicians, other healthcare professionals, survivors, patients and advocates every year to share the latest breakthroughs and developments in cancer science and medicine. Last year, the 2024 Annual Meeting attracted 23,000 in-person attendees and 6,700 online participants from 78 countries.
In recent years, CK Life Sciences has regularly participated at the AACR Annual Meeting. The 2025 Annual Meeting will be held from 25-30 April. At the event, CK Life Sciences will exhibit posters highlighting data from preclinical studies of investigational cancer vaccines programs targeting (i) PRAME (Preferentially Expressed Antigen in Melanoma), (ii) PD-L1 (programmed cell death ligand 1), (iii) B7-H3 (B7 homolog 3) and (iv) Claudin 6 proteins, respectively.
PRAME is a protein highly expressed in several cancers, including melanoma, liver cancer and leukemia.
PD-L1 is one of the most important immune checkpoint proteins that is highly expressed in cancer cells to block T cell activation in the tumour microenvironment.
B7-H3 is another immune checkpoint protein that modulates T cell responses and is often overexpressed in cancer.
Claudin 6 is a tight junction protein that regulates epithelial barrier integrity and is overexpressed in cancers like breast cancer, lung cancer and endometrial cancer, where it is associated with tumour progression and metastasis.
In addition, CK Life Sciences will be co-presenting with our research collaborator two posters showcasing our Artificial Intelligence (AI)-empowered platform for designing cancer vaccines.
“CK Life Sciences is pleased with the preclinical efficacy results of its investigational cancer vaccines targeting PRAME, PD-L1, B7-H3 and Claudin 6 proteins, and we hope to further advance the research & development of these and other cancer vaccines. We are also excited about the progress achieved in our efforts to develop an AI platform aimed at designing cancer vaccines that are more likely to be immunogenic and clinically effective,” said Melvin Toh, Vice President and Chief Scientific Officer at CK Life Sciences.
Dr. Toh continued, “CK Life Sciences is determined to accelerate its R&D to benefit cancer patients. Currently, a number of therapeutic cancer vaccines are in clinical and discovery/preclinical research stages. Amongst them, seviprotimut-L, a cancer vaccine already in the final research stage, is being tested for the adjuvant treatment of stage IIB or IIC melanoma following definitive surgical resection.
DETAILS ON POSTER PRESENTATIONS:
- Abstract 853: PDL1-PRAME dual antigen cancer vaccine inhibits melanoma growth in syngeneic mouse model and induces antigen-specific immune responses
Session Category: Clinical Research
Session Title: Vaccines and Cell Therapies
Session Date and Time: 4/27/2025 2:00 PM – 5:00 PM
Location: Poster Section 35
Poster Board Number: 9
- Abstract 3533: Claudin 6 vaccines effectively inhibit tumor growth in a syngeneic mouse colon cancer model
Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 39
Poster Board Number: 9
- Abstract 3536: Synergistic effects of combined PD-L1 and B7-H3 fusion protein vaccination in a mouse model of pancreatic cancer
Authors: Kenneth Nansheng Lin, Melvin Toh, Hong Wang
Session Category: Immunology
Session Title: Vaccines, In Situ Vaccines, and Vaccine Combinations
Session Date and Time: 4/28/2025 2:00 PM – 5:00 PM
Location: Poster Section 39
Poster Board Number: 12
- Abstract 3538: The development of neoantigen-derived peptide vaccine driven by AI epitope design and computer assisted epitope enhancement
Session
Category:
Immunology
Session
Title:
Vaccines,
In
Situ
Vaccines,
and
Vaccine
Combinations
Session
Date
and
Time:
4/28/2025
2:00
PM
–
5:00
PM
Location:
Poster
Section
39
Poster
Board
Number:
14
- Abstract 3649: Artificial intelligence accelerates shared neoantigen peptide cancer vaccine development
Session
Category:
Bioinformatics/
Computational
Biology/
Systems
Biology/
Convergent
Science
Session
Title:
Artificial
Intelligence
and
Machine
Learning
for
Therapeutic
Election
and
Discovery
Session
Date
and
Time:
4/28/2025
2:00
PM
–
5:00
PM
Location:
Poster
Section
45
Poster
Board
Number:
11
The full abstracts are available in the AACR Online Itinerary Planner, which can be accessed at: https://www.abstractsonline.com/pp8/#!/20273
DISCLAIMER
This
press
release
may
contain
forward-looking
statements
regarding
the
Group’s
research
and
development
projects
which
may
involve
risks
and
uncertainties.
Actual
results
may
differ
materially
from
expectations
discussed
in
such
forward-looking
statements.
All information in this press release is for general reference only and is not intended as investment advice or medical advice. CK Life Sciences Int’l., (Holdings) Inc. does not warrant or represent, express or implied, as to the accuracy, completeness or updated status of such information. No liability will be accepted for any loss or damage howsoever arising from or in reliance upon such information.
Copyright ©2025 CK Life Sciences Int’l., (Holdings) Inc. All rights reserved.
Hashtag: #CKLifeSciences #CancerVaccines #R&D #Pharmaceutical #AmericanAssociationforCancerResearch #AACR #PRAME #PD-L1 #B7-H3 #Claudin6Proteins #Melanoma #AI
The issuer is solely responsible for the content of this announcement.
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