Spurs and Liverpool qualified after winning Group J and B respectively, while United finished third in their Champions League Group B.
They are all seeded and will play one of 16 unseeded sides – made up of 12 group runners-up and four of the teams eliminated from the Champions League.
United could be drawn against Gary Neville’s Valencia of Spain.
Support InfoStride News' Credible Journalism: Only credible journalism can guarantee a fair, accountable and transparent society, including democracy and government. It involves a lot of efforts and money. We need your support. Click here to Donate